Osmoregulation: by controlling and increasing the length of the loop of Henle and the concentration of brine within the medulla of the kidney, they are able to survive almost entirely on metabolic water. It also regulates through hair and sweat glands.Respiration: The lungs are the respiratory organs. The air passageway is formed by the external nostrils, the pharynx, the larynx, the trachea and the bronchi. The lungs contain a large number of minute alveoli in which external respiration occurs. Surrounding the lungs and heart is a rib cage containing long, curved bones called ribs. Below the lungs is a diaphragm that divides the trunk into the upper chest and lower abdomen. The ribs and diaphragm play an important role in the inhalation and exhalation of respiratory movement. Impact on humans: It has been used extensively in medical and genetic research. It has enormous importance in physiology, genetics, immunology, pathology and epidemiology. Similarly, there is a negative impact on human beings too. It carries rat-borne diseases that kill people. It also carries diseases such as plague, typhus, trichinosis, tularemia, infectious jaundice and many other serious diseases. It is the enormous destroyer of property, including crops, human food storage and parts thereof