Howard Robard Hughes (December 24, 1905 – April 5, 1976), a pilot, film producer, playboy and one of the richest people in the world during his lifetime, was well known for his eccentricity . His eccentric behavior is theorized to be the result of obsessive-compulsive behavior. The intent of this review is to illustrate Mr. Hughes' abnormalities, arrive at a clinical diagnosis using all five axes of the Diagnostic and Statistical Manual of Mental Disorders IV-TR (DSM-IV-TR), explain his behavior from a biological theoretical point of view, and finally to arrive at a hypothetical treatment plan. Behavior: To begin with, what constitutes abnormal behavior in the case of Mr. Hughes? As early as the 1930s, Hughes showed signs of obsessive-compulsive disorder. OCD is identified by the DSM as characterized by recurrent obsessions (persistent thoughts, ideas, impulses, or images that seem to invade a person's consciousness) or compulsions (repeated, rigid behaviors or mental acts that people feel they must perform to prevent or reduce anxiety) (Cormer, 2008). Close friends reported that Hughes was obsessed with the size of peas, one of his favorite foods, and used a special fork to sort them by size. Those who interacted with him as a director commented on his obsessions. While directing a film, Hughes zeroed in on a small flaw in an actress's top, claiming that the fabric bunched up along a seam and gave the appearance of two nipples on each breast. He was reportedly so upset by the issue that he wrote a detailed memorandum to the crew on how to resolve the problem (Hack, 2002). An executive producer who worked with Hughes wrote in his autobiography about the difficulty of dealing with the t...... middle of paper ...... h proved that physical exercise, outdoor activity and socialization lead to increased serotonin levels and overall health (Young, 2007). Although biological treatment consisting of drug therapy, physical therapy, and nutritional therapy will begin to produce the desired results toward a cure, the prognosis for recovery from this disorder would be greatly improved by a combination of behavioral and cognitive measures. and pharmacological therapies. Patients who receive a combination of such therapies achieve greater relief from their symptoms than either approach alone (Kordon et al., 2005). It is unfortunate that Mr. Hughes was unable to receive adequate help for his disorder during his lifetime. Given the above treatment plan, along with the benefits of current research and Mr. Hughes' wealth to receive the best care, his prognosis in current times would have been quite good.