Introduction Dengue fever is a tropical disease produced by a virus transmitted by an Aedes aegipti mosquito. This disease mainly affects tropical countries in Latin America, Africa and Asia, and according to the World Health Organization (WHO), dengue is a rapidly expanding emerging pandemic viral disease and is one of the four vaccination priorities future of the WHO. (WHO, 2013) Researchers in the United States, Brazil and Europe have developed 4 vaccine candidates that are in clinical trials. These assessments were carried out in topical countries such as Colombia, Brazil, Thailand and Singapore. In parallel with this race to develop a vaccine, a Dengue Vaccine Initiative (DVI) has emerged to accelerate the introduction of these vaccines in developing countries using the knowledge and experience of local researchers. Throughout this process researchers, laboratories, universities, companies and national health institutes were involved, creating an intersection between regional innovation systems (Medellin Ruta N), health clusters and technological innovation systems for vaccine technology, overcoming geographical boundaries. National innovation systems also impact the outcomes we are seeing today. In this essay I aim to describe how the intersection of 4 innovation systems occurred; national, regional, sectoral and technological in the clinical evaluation of DENVax, one of the vaccine candidates developed by Invitrogen in the United States and evaluated in Colombia by the PECET research group in the city of Medellin. Description of the ecosystem and national capabilities to develop vaccine candidates. Due to the impact this disease could have worldwide, efforts have been made to develop a tetravalent vaccine that creates... middle of paper... technical service. Conclusions The related variety uses the idea of ​​cognitive distance to evaluate the extent to which knowledge can spread or be transferred between sectors. It is argued that learning and knowledge transfer are facilitated when there is a technological correlation between sectors, so the cognitive distance is neither too great for learning to occur, nor so close as to hinder novelty. (Asheim, Smith, & Oughton, 2011) Third, there is a need to improve our understanding of the dynamics of RIS and the emergence and evolution of new knowledge-intensive industries, such as nanotechnology. In particular, consider what factors shape the evolution and performance of knowledge-intensive industries within RIS as they go through different phases of development, growth and consolidation (PORTER et al., 2005). This could be one of my survey questions??????