Topic > The Immune System: The Innate Immune System

First, mast cells, once again, originate from an individual's bone marrow and focus primarily on the individual's tissues (Sherwood et al., 2014). They contain many important chemicals that support the inflammatory response and provide support for regular infections and allergic reactions (“About Mast Cells…”, n.d.). Monocytes have the ability to transform into macrophages and dendritic cells, but more on this later. The main function of a monocyte is to mature into its subsequent counterparts (Sherwood et al., 2014). Think of it as a stepping stone to macrophages and dendritic cells. Macrophages are much larger than monocytes, hence the name. They work by finding a pathogen and ingesting it through phagocytosis (Sherwood et al., 2014). A macrophage can be classified into two different types: M1 and M2. M1 macrophages are incredibly aggressive when presented with a pathogen, and as a result, the body responds with an acute inflammatory response. M2 macrophages act in a completely opposite way, they react a little slower to pathogens and their inflammatory response is much smaller in comparison (Promo Cell, 2014). Moving forward, dendritic cells are very similar to macrophages as they are relatives of each other. Another reason they are similar is that they help fill in the answers